Liquid Biopsy Methylation and Mutation in papillary thyroid cancer
Liquid Biopsy Methylation and Mutation in papillary thyroid cancer
Members of the Research Committee
Dr. Seyed Mohammad Tavangar
Dr. Ramin Heshmat
Dr. Bagher Larijani
Presented by: Fatemeh Khatami
Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences
Email : f-khatami@farabi.tums.ac.ir
Liquid Biopsy A test done on a sample of blood to look for cancer cells from a tumor that are circulating in the blood or for pieces of DNA from tumor cells that are in the blood.
A liquid biopsy is a simple and non-invasive alternative to surgical biopsies which enables doctors to discover a range of information about a tumor through a simple blood sample. Traces of the cancer's DNA in the blood can give clues about which treatments are most likely to work for that patient.
A liquid biopsy may be used to help find cancer at an early stage. It may also be used to help treatment plan or to find out how well treatment is working for cancer recurrence.
Reliable, noninvasive methods of cancer detection.
Being able to take multiple samples of blood over time may also help doctors understand what kind of molecular changes are taking place in a tumor.
Signatures of patients’ tumors can be characterized molecularly; aids in understanding tumor biology and may be the best tool for monitoring , therapeutic response and perhaps, early detection and personalized cancer management.
Real time representative of tumors
Papillary Thyroid Carcinoma (PTC) is the most common thyroid cancer ( 80% of all thyroid cancers cases)
The diagnostic procedures of thyroid nodules include ultrasound examination of the neck and cytological analysis of Fine Needle Aspiration (FNA).
90% of the nodules are classified as benign, and 3.5% – 5% as malignant, 15% of nodules are diagnosed as undetermined by cytological examination of FNA
80% of the thyroid FNA samples that were classified as indeterminate by cytology will undergo
an unnecessary diagnostic
thyroidectomy, which has its
own risk of complications
